Re: Quantum Biology, cont.

Date: Wed, 4 Sep 1996 20:28:09 -0700 (PDT)
From: Lawrence B. Crowell <lcrowell@unm.edu>
To: quantum-d@teleport.com
Subject: Re: Quantum Biology, cont.

Quantum Biology, cont.

   The suggestion of interfacing microtubules with buckytubes
   is elaborated...

> Date: Wed, 4 Sep 1996 11:09:13 -0700 (PDT)
> From: "Lawrence B. Crowell" 
> To: MR JAMES N ROSE 
> Cc: lcrowell@unm.edu
> Subject: Re: Your Quantum-D post
>
> On Wed, 4 Sep 1996, MR JAMES N ROSE wrote:
>
> > Date: Wed,  4 Sep 1996 01:38:11, -0500
> > From: MR JAMES N ROSE 
> > To: lcrowell@unm.edu
> > Subject: Your Quantum-D post
> >
> > Excellent post!
> >
> > quantum gravity tends to make the MT thesis a house of straw.
>
> I think the interest with quantum gravity in this issue is that quantum
> black holes lead to decoherence of wave functions.  This is similar to
> what happens with a quantum measurement.  The problem with quantum gravity
> is that this domain occurs on a scale of 10^-33 cm.  The supercollider
> would have probed nature on the scale of 10^-17 cm.  While I devoted a
> great deal of study and work on strings and quantum gravity, I felt that
> it was not likely to be an experimental arena of physics.  The funding
> problems with science in the 1990's makes it imperitive to work in a
> domain that has an active experimenal component.  Rather few people who
> study quantum gravity are finding positions.
>
> > Buckytubes seem a reasonable re-construction of MT's.  The primary
> > concern would be insulating them from extraneous disruptive damage,
> > since they would not be able to self repair.  Then again, maybe they
> > are robust enough to where that wouldn't be a worry.
>
> There is a way to fix this.  Many macromolecules are formed with ribose
> and a purine or pyrimadine.  These certainly include RNA, but also include
> NADH, coA, and other coenzymes.  The fundamental blocks are molecules of
> the form
>
>                    /----\          /\
>                   /      \N_______/  \
>                   \      /        \__/
>                    \----/
>
> where the hex is usually a nucleoside, and the pent is a ribose sugar. If
> the nucleoside is adenine and 1,2, or 3 phosphates are linked to the other
> side, then you have AMP, ADP, or ATP, as the case may be, which are in-
> volved with cellular respiration.  Now these molecules form weak hydrogen
> bonds, such as with the pairing of RNA and DNA.  This is the anchor to
> work with.
>
> Say we have a Helmholtz coil that creates a uniform magnetic field in
> between the two loops.  This creates a magnetic potential well.  Further,
> we have 6 masers that direct microwave electromagnetic waves in the 3
> coordinate directions.  There is a resonant frequency associated with this
> hydrogen bond, so we can get a dipole interaction with the macromolecules
> with the EM field.  This has the tendency to trap the molecule.  This will
> partially eliminate the jitter seen in the cytoplasm of the cell. The
> molecules will tend to settle into a spot where there is no doppler
> shifting of the radiation from any direction.  This freeze framing of the
> intercellular medium should porevent the breakage of fibres and tubes,
> and allow for the accurate guiding of the probe to a specific site.
>
> Now we take a buckytube, or molecular fibre, and attach a tRNA molecule to
> a p bond at the end.  This then finds its way to the receptor site on a
> ribosome.  We could similarly place an amino acid on the fibre by removing
> the hydrogen on the carboxyl group and allowing it to bond to the fibre.
> A second tube then probes the surface of the ribosome.  There is a Gibbs
> free energy associated with the chemical interaction that should be
> detectable.  Further the charge distribution on the ribosome surface will
> change.  This can then be detected and mapped.  It seems possible to image
> macromolecules in vitro and to measure on the molecular level the dynamics
> of these processes.
>
> As for microtubules much the same would be done.  These objects are formed
> from alpha and beta tubulin dimes that are linked by GTP ----> GDP
> process..  The GDP forms the moter between these two molecules that form a
> dimer chain.   This site allows for microtubule associated molecules MAPs
> to bind to MT's. The kinesin or dynein that forms the bond to the MT's
> could be chemically grafted onto the buckytube.  This then gives us a
> reasonable link to the inner workings of the MT's to determine if quantum
> effects really play a role.
>
> > At least you didn't throw the baby out with the bathwater!
> >
> > I've only been on-line since June. Have you posted elsewhere?
>
> I have some things with J. Sarfatti.  His site is pretty easy to find on
> www with netscape.
>
> Lawrence B. Crowell
>
> > Jamie Rose
> > INTEGRITY PARADIGM
> > hrsg57a@prodigy.com
> >
>
>